• Breeze 2.0: An interactive web-tool for visual analysis and comparison of drug response data 

      Potdar, Swapnil; Ianevski, Filipp; Ianevski, Aleksandr; Tanoli, Ziaurrehman; Wennerberg, Krister; Seashore-Ludlow, Brinton; Kallioniemi, Olli; Ostling, Paivi; Aittokallio, Tero Antero; Saarela, Jani (Peer reviewed; Journal article, 2023)
      Functional precision medicine (fPM) offers an exciting, simplified approach to finding the right applications for existing molecules and enhancing therapeutic potential. Integrative and robust tools ensuring high accuracy ...
    • Differentiation status of primary chronic myeloid leukemia cells affects sensitivity to BCR-ABL1 inhibitors 

      Pietarinen, Paavo O; Eide, Christopher A; Ayuda-Duran, Maria del Pilar; Potdar, Swapnil; Kuusanmäki, Heikki; Andersson, Emma I; Mpindi, John P; Pemovska, Tea; Kontro, Mika; Heckman, Caroline A.; Kallioniemi, Olli; Wennerberg, Krister; Hjorth-Hansen, Henrik; Druker, Brian J; Enserink, Jorrit; Tyner, Jeffrey W.; Mustjoki, Satu; Porkka, Kimmo (Peer reviewed; Journal article, 2017)
      Tyrosine kinase inhibitors (TKI) are the mainstay treatment of BCR-ABL1-positive leukemia and virtually all patients with chronic myeloid leukemia in chronic phase (CP CML) respond to TKI therapy. However, there is limited ...
    • Multi-modal meta-analysis of cancer cell line omics profiles identifies ECHDC1 as a novel breast tumor suppressor 

      Jaiswal, Alok; Gautam, Prson; Pietilä, Elina A; Timonen, Sanna; Nordström, Nora; Akimov, Yevhen; Sipari, Nina; Tanoli, Ziaurrehman; Fleischer, Thomas; Lehti, Kaisa; Wennerberg, Krister; Aittokallio, Tero Antero (Journal article; Peer reviewed, 2021)
      Molecular and functional profiling of cancer cell lines is subject to laboratory-specific experimental practices and data analysis protocols. The current challenge therefore is how to make an integrated use of the omics ...